In 2004, STOP AIDS NOW!, a partnership between Aids Fonds, ICCO, Cordaid, Hivos, and Oxfam Novib, was looking for ways to more effectively address the needs of orphans and other vulnerable children in South Africa. To do this, the five Dutch STOP AIDS NOW! Partners as well as two other Dutch organisations – the World Population Fund and Save the Children Netherlands – identified ten South African organisations and asked them to form their own partnership to work on this issue. As partnership can be an important vehicle for increasing the effectiveness of developmental work, this document seeks to share what STOP AIDS NOW! has learned from their experience about making partnership work. These lessons can help others who are contemplating starting, strengthening or supporting developmental partnerships, as well as those already actively involved in them.